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| 用于膀胱癌治疗的载药光敏剂研究 |
| Research of drug-carrying photosensitizers for bladder cancer therapy |
| 投稿时间：2025-01-20 |
| DOI：10.3969/j.issn.1005-5630.202501200010 |
| 中文关键词: 吲哚菁绿 光热治疗 光动力治疗 膀胱癌 |
| 英文关键词:indocyanine green photothermal therapy photodynamic therapy bladder cancer |
| 基金项目:上海市科委“科技创新行动计划”项目（22140900900） |
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| 中文摘要: |
| 成功设计并合成了一种经PVP修饰的，负载吲哚菁绿（indocyanine green，ICG）的BiF3介孔纳米球（BFPI）。BFPI具有优异的水分散性，可有效解决ICG对有机溶剂的依赖问题，并且能够被膀胱癌细胞高效摄取。在808 nm激光照射下，ICG可产生具有强氧化性的活性氧物质（reactive oxygen species，ROS），有效杀伤膀胱癌细胞。同时，ICG的高光热转换效率使其在近红外光照射下能迅速产生光热效应，进一步增强对膀胱癌细胞的杀伤能力。在808 nm激光照射下，BFPI能够成功诱导膀胱癌细胞焦亡。在显微镜下，可观察到膀胱癌细胞呈现出典型的焦亡形貌。综上所述，BFPI作为一种新型纳米材料，为膀胱癌的光疗研究提供了一种有效的策略。 |
| 英文摘要: |
| In this study, we successfully designed and synthesized a nanomaterial, which is PVP-modified BiF3 mesoporous nanospheres loaded with indocyanine green (ICG). BFPI possesses excellent aqueous dispersibility, which effectively solves the problem of ICG's dependence on organic solvents and can be efficiently taken up by bladder cancer cells. Under 808 nm laser irradiation, ICG can generate reactive oxygen species (ROS) with strong oxidizing properties, which can effectively kill bladder cancer cells. Meanwhile, the high photothermal conversion efficiency of ICG enables it to rapidly generate photothermal effect under near-infrared light irradiation, which further enhances the killing ability of bladder cancer cells. Under 808 nm laser irradiation, BFPI is able to successfully induce pyroptosis of bladder cancer cells, which shows the classical pyroptosis morphology under the microscope. In summary, BFPI as a novel nanomaterial, provides an effective strategy for phototherapy of bladder cancer. |
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