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| 基于有限元分析的固体微针力学性能研究及其集成阵列制备与表征 |
| Investigation of the mechanical properties of solid microneedles via finite element analysis with fabrication and characterization of integrated arrays |
| 投稿时间：2024-12-26 |
| DOI：10.3969/j.issn.1005-5630.202412260114 |
| 中文关键词: 微针 经皮给药 有限元分析 结构力学模拟 |
| 英文关键词:microneedles transdermal drug delivery finite element analysis structural mechanics simulation |
| 基金项目:上海市科委“科技创新行动计划”项目（23141901300） |
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| 中文摘要: |
| 微针作为新型经皮药物输送系统，具有持续给药、最小侵入性等优点，但材料选择和力学性能优化仍需研究。基于ANSYS有限元法，模拟了圆锥形、四棱锥形、立方碑形微针插入皮肤时的力学行为，对比了硅、不锈钢、树脂等材料的性能。结果表明，圆锥形微针位移最大（5.550e–5 mm）、内部应力最小（3.315 MPa），且在0.01 N压力下，圆锥形不锈钢微针的最大Von Mises应力为42.104 MPa，穿透力强。通过光固化3D打印制备了19×19圆锥形微针阵列，采用顺序浇注法制备CMC/MAL微针，显微镜下形貌均匀光滑，穿刺力为0.01 N/针，满足皮肤穿刺需求。研究为微针设计与优化提供了理论依据和实验支持。 |
| 英文摘要: |
| Microneedles (MNs), as a novel transdermal drug delivery system (TDDS), offer advantages such as sustained drug delivery and minimal invasiveness, but further research is needed in material selection and mechanical performance optimization. This study employed the finite element method (FEM) based on ANSYS to simulate the mechanical behavior of conical, square pyramid, and cuboid microneedles during skin insertion, comparing the performance of materials such as silicon, stainless steel, and resin. The results showed that conical microneedles exhibited the maximum displacement (5.550e–5 mm) and minimum internal stress (3.315 MPa). Under a 0.01 N axial force, the conical stainless steel microneedle demonstrated strong penetration ability, with a maximum Von Mises stress of 42.104 MPa. A 19×19 conical microneedle array was fabricated using light-curing 3D printing, and CMC/MAL microneedles were prepared via a sequential casting method. Morphological characterization revealed uniform and smooth surfaces, with a puncture force of 0.01 N/needle, meeting skin penetration requirements. This study provides theoretical and experimental support for the design and optimization of microneedles. |
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