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| 太赫兹光谱技术应用于艾绒中松油醇的检测 |
| Application of terahertz spectroscopy technology in detection of terpineol in moxa wool |
| 投稿时间：2024-03-26 |
| DOI：10.3969/j.issn.1005-5630.202403260062 |
| 中文关键词: 松油醇 艾绒 太赫兹 偏最小二乘法 |
| 英文关键词:terpineol moxa wool terahertz partial least squares method |
| 基金项目:上海市自然科学基金 (21ZR1444700) |
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| 中文摘要: |
| 艾绒作为中药宝藏之一，其药理成分包括挥发油、黄酮类、萜类等，其中松油醇具有抗炎和镇痛作用。传统化学方法在检测艾绒中松油醇含量方面存在样品预处理复杂、分析耗时、成本较高等问题。而采用太赫兹光谱技术对艾绒中松油醇进行快速无损检测，不仅检测效率高，还具有灵敏度高、操作简便等优势。通过将太赫兹光谱的特征峰位与分子模拟得到的振动模式比对，借助 “指纹谱” 实现了对艾绒中松油醇的定性检测；利用特征峰的峰面积则实现了定量检测。采用偏最小二乘法进行线性拟合，松油醇含量的预测值与实际值的相关系数达到 0.99。该研究为艾绒质量鉴别提供了新方法，为中药质量检测开创了新思路。 |
| 英文摘要: |
| Moxa wool, renowned as a treasure trove of traditional Chinese medicine, harbors pharmacologically active constituents including terpineol, flavonoids, and terpenoids, among which terpineol exhibits notable anti-inflammatory and analgesic properties. Conventional chemical methodologies encounter technical challenges such as complex sample preparation, time-consuming analysis, and high costs in determining the content of terpineol in moxa wool. Instead, the use of terahertz spectroscopy for rapid and non-destructive detection of terpineol in moxa wool not only improves detection efficiency, but also offers advantages such as high sensitivity and simple operation. By comparing the characteristic peaks in terahertz spectra with the vibrational modes obtained from molecular simulations, qualitative detection of terpineol in moxa wool was achieved through "spectral fingerprints". Quantitative detection was accomplished through the peak area of characteristic peaks. After linear fitting using partial least squares (PLS) regression, the correlation coefficient between the predicted and actual terpineol contents reached 0.99. The research establishes a novel approach for quality authentication of moxa wool and offering fresh perspectives for quality assessment in traditional Chinese medicine. |
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