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| 振动强耦合对白蛋白光谱特性和功能性质的影响 |
| The impact of vibrational strong coupling on the spectral characteristics and functional properties of albumin |
| 投稿时间：2024-02-15 |
| DOI：10.3969/j.issn.1005-5630.202402150021 |
| 中文关键词: F-P微腔 振动强耦合 荧光检测 |
| 英文关键词:F-P microcavity vibrational strong coupling fluorescence detection |
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| 摘要点击次数: 1061 |
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| 中文摘要: |
| 用振动强耦合（vibrational strong coupling，VSC）调节结构性质的方法逐渐被大众所熟知。置于光学谐振腔内的分子系统受到能量影响可能会发生性质改变。牛血清白蛋白（bovine serum albumin，BSA）是一种常用的蛋白质，当性质发生改变时，它的变化效果尤为明显。当用谐振腔将其调节至与水分子共振耦合的状态时，溶液状态下的BSA性质会改变。调节水分子与腔模式之间的耦合强度时，白蛋白自身的结合效果会随着耦合强度的改变发生相应改变。利用3种不同的表征方法，发现BSA的光谱性质发生了显著变化。该研究首次证实，通过VSC技术可实现蛋白质功能性质的物理调控，为生物医药领域开发新型蛋白调控策略提供了重要思路。 |
| 英文摘要: |
| The method of regulating the structural properties through vibrational strong coupling (VSC) is gradually becoming known to the public. The molecular system placed in an optical resonator may undergo changes in properties due to energy impact. Bovine serum albumin (BSA) is a commonly used protein, and its effects on different changes are particularly pronounced. When using a resonant cavity to adjust to a state resonantly coupled with water molecules, it affects the properties of BSA albumin in solution. By tuning the coupling strength between water molecules and cavity modes, it is observed that the binding effect of albumin itself changes correspondingly with the coupling strength. Furthermore, by employing three different characterization methods, significant changes in its spectral properties are discovered. This study is the first to confirm that the physical regulation of protein functional properties can be achieved through VSC technology, providing important insights for developing novel protein modulation strategies in the field of biomedicine. |
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