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| 基于太赫兹衰减全反射光谱法的无创血糖检测研究 |
| Study on non-invasive blood glucose measurement based on terahertz attenuated total reflection spectroscopy |
| 投稿时间：2019-04-23 |
| DOI：10.3969/j.issn.1005-5630.2019.06.002 |
| 中文关键词: 太赫兹 衰减全反射式 无创 血糖检测 |
| 英文关键词:terahertz attenuated total reflection non-invasive blood glucose measurement |
| 基金项目:上海市浦江人才计划（17PJD028）；国家自然科学基金（61671302）；上海市曙光计划（18SG44） |
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| 中文摘要: |
| 结合太赫兹时域光谱系统，利用棱镜衰减全反射技术，设计了一种太赫兹衰减全反射光谱法的无创血糖检测系统。借助德拜模型分析了皮肤中含水量变化会影响皮肤在太赫兹波段的弛豫作用，得到皮肤复折射率与皮肤含水量的关系，利用菲涅耳公式给出了计算皮肤复折射率实部和虚部的方法。将太赫兹光谱法测得的人体大拇指皮肤复折射率的实部与虚部，与口服葡萄糖耐量试验实际测得的人体血糖浓度进行对比，得到了人体手指皮肤的太赫兹反射谱以及复折射率与人体血糖浓度成正相关的关系，为太赫兹应用于无创血糖浓度检测提供了参考。 |
| 英文摘要: |
| Based on terahertz time-domain spectroscopy and prism attenuated total reflection technique, we design a non-invasive blood glucose detection system with terahertz wave reflectance spectroscopy. With the help of Debye model, it is found that the change of water content in the skin can affect the relaxation of the skin in terahertz band. The relationship between the complex refractive index of the skin and the water content of the skin is obtained. The method of calculating the real part and imaginary part of skin refractive index is given by means of Fresnel formula. The real and imaginary parts of the complex refractive index of human thumb skin measured by terahertz spectroscopy are compared with the actual human blood glucose concentration measured by oral glucose tolerance test. The relationship between the terahertz reflection spectrum and complex refractive index of human thumb skin are positively correlated with human blood glucose concentration. It provides a new method for the application of terahertz in noninvasive blood glucose concentration detection. |
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